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ORIGINAL ARTICLE
Year :   |  Volume :   |  Issue :   |  Page :
 

'Hot gall bladder service' by emergency general surgeons: Is this safe and feasible?


 Department of General Surgery, William Harvey Hospital, Ashford, Kent, UK

Date of Submission22-Oct-2020
Date of Decision21-Jan-2021
Date of Acceptance18-Feb-2021
Date of Web Publication16-Apr-2021

Correspondence Address:
Mohammad Imtiaz,
East Kent University Hospital NHS Trust, William Harvey Hospital, Ashford, Kent TN24 0LZ
UK
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmas.JMAS_271_20

  Abstract 

Background: Despite NICE/AUGIS recommendations, the practice of early laparoscopic cholecystectomy (ELC) has been particularly poor in the UK offered only by 11%–20% surgeons as compared to 33%–67% internationally, possibly due to financial constraints, logistical difficulties and shortage of expertise, thus, reflecting the varied provision of emergency general surgical care. To assess whether emergency general surgeons (EGS) could provide a 'Hot Gall Bladder Service' (HGS) with an acceptable outcome.
Patients and Methods: This was a prospective HGS observational study that was protocol driven with strict inclusion/exclusion criteria and secure online data collection in a district general hospital between July 2018 and June 2019. A weekly dedicated theatre slot was allocated for this list.
Results: Of the 143 referred for HGS, 86 (60%) underwent ELC which included 60 (70%) women. Age, ASA and body mass index was 54* (18–85) years, II* (I-III) and 27* (20–54), respectively. 86 included 46 (53%), 19 (22%), 19 (22%) and 2 (3%) patients presenting with acute calculus cholecystitis, gallstone pancreatitis, biliary colic, and acalculus cholecystitis, respectively. 85 (99%) underwent LC with a single conversion. Grade of surgical difficulty, duration of surgery and post-operative stay was 2* (1–4) 68* (30–240) min and 0* (0–13) day, respectively. Eight (9%) required senior surgical input with no intra-operative complications and 2 (2%) 30-day readmissions. One was post-operative subhepatic collection that recovered uneventfully and the second was pancreatitis, imaging was clear requiring no further intervention.
Conclusion: In the current climate of NHS financial crunch, COVID pandemic and significant pressure on inpatient beds: Safe and cost-effective HGS can be provided by the EGS with input from upper GI/HPB surgeons (when required) with acceptable morbidity and a satisfactory outcome.
*Median


Keywords: Emergency general surgeon, hot gall bladder service, laparoscopic cholecystectomy



How to cite this URL:
Imtiaz M, Prakash S, Iqbal S, Fernandes R, Shah A, Shrestha AK, Basu S. 'Hot gall bladder service' by emergency general surgeons: Is this safe and feasible?. J Min Access Surg [Epub ahead of print] [cited 2021 Jun 14]. Available from: https://www.journalofmas.com/preprintarticle.asp?id=313934

Sara Iqbal Joint second author



  Introduction Top


Emergency surgical patients account for 50% of the general surgical workload and 80%–90% of the surgical mortalities. Despite this for decades, the provision for emergency general surgical care across the U. K. has lacked uniformity. The Royal College of Surgeons of England (RCS) and the Association of Surgeons of Great Britain and Ireland (ASGBI) in 2013 requested an urgent review of the provision and outcomes of emergency general surgery and explore options for new service delivery.[1]

Approximately 10%–15% of the adult UK population suffer from gallstone (GS) diseases and 20% of these become symptomatic due to biliary colic, acute cholecystitis, cholangitis, pancreatitis and obstructive jaundice.[2] Gallstone-related diseases account for one-third of emergency general surgical admissions.[3] Early laparoscopic cholecystectomy (ELC) for the acute presentation from the gallstone diseases for years were fraught with concerns of higher conversion and morbidity. Patients were routinely managed conservatively and were followed by interval cholecystectomy (>6 weeks later).[4] ELC has now been accepted as the treatment of choice for acute cholecystitis that has superseded the earlier practice of conservative management and delayed cholecystectomy.[5],[6] National Institute for Health and Care Excellence (2014) recommended patients with acute cholecystitis to have a laparoscopic cholecystectomy (LC) within a week of diagnosis and patients with gallstone pancreatitis to have LC on index admission for its benefits of fewer complications and readmissions, lower hospital costs, fewer work days lost and greater patient satisfaction.[2],[7] Despite positive evidence and recommendations, the rate of ELC still remains low worldwide,[8],[9],[10] possibly due to financial constraints, logistical difficulties and shortage of expertise.[2],[5],[8] Practice of ELC has been particularly poor in the UK offered only by 11%–20% surgeons as compared to 33%–67% internationally, once again reflecting the varied provision of emergency general surgical care.[8],[11],[12],[13]

The RCS of England and the ASGBI recommends dedicated 'Emergency Surgical Service' delivered by dedicated team to improve patient care.[1],[14] In November 2014, trust reorganised and redesigned the emergency services with the establishment of the surgical emergency assessment unit (SEAU) through the placement of a dedicated resident surgical team supervised by the on-call surgical registrar. The average monthly surgical admissions dropped by 34% by 2017 compared to the pre-SEAU era. This success encouraged the surgical division for further reconfiguration of acute general surgical care that leads to the appointment of four emergency general surgeons (EGS) from November 2017 and SEAU being led during the day by the resident dedicated consultant EGS.

Evidence has confirmed hot gallbladder surgery to be safe and cost-effective[15],[16],[17],[18] and is associated with reduced hospital stays with no difference in conversion rates, morbidity and/or mortality.[19] Inspired by the positive outcome of the SEAU, the appointment of the EGSs and obtainment of a dedicated weekly theatre list led to the establishment of a dedicated 'Hot Gall Bladder Service (HGS)' from July 2018 to address patients of acute symptomatic gallstone diseases in line with the NICE/AUGIS recommendations.

The primary aim of this prospective observational study was to ascertain whether EGSs with laparoscopic experience could provide a safe and effective HGS. The secondary aim was to review intra operative and post-operative complications, conversion rates, length of stay (both total and post-operative) and 30-day readmissions.


  Patients and Methods Top


This was a 12-month study of the acute management of patients of gallstone diseases presenting to a district general hospital (DGH) in the southeast of England from July 2018 to June 2019.

Following approval from the local ethical committee, this study was strictly protocol-driven that was devised to triage patients with gall stone diseases appropriate for the 'Hot Gallbladder Service' incorporating the national guidelines as regards their time of intervention.

Inclusion criteria included: Patients aged 18 and above presenting to the hospital with symptoms related to proven gallstones: Recurrent biliary colic and those within 7 days of onset of acute cholecystitis, gallstone pancreatitis and patients with gallstone disease but clear biliary tree (following MRCP/ERCP). Exclusion criteria were: Patients below 18 years, fails the inclusion criteria, inability to provide consent and those not fit for operative intervention.

Surgical emergency assessment unit

The emergency general surgical care for our patients changed following the appointment of four emergency general surgical consultants from November 2017. They are competent laparoscopic general surgeons with <2-years' experience as consultant surgeons. A typical week was split into Monday to Thursday and Friday to Sunday. The four EGSs followed a rolling 1:4 rotating on-call from Monday to Thursday that was designed to ensure on-site consultant presence free from all elective commitment 10 h a day (0800-1800P. M) with twice daily ward rounds. The night (0800-1800P. M) and weekends (Friday to Sunday) were shared with the other five non-EGSs (four colorectal and one upper gastrointestinal). This allowed sub-specialist elective commitment to continue uninterrupted.

The general surgical division was successful in acquiring a dedicated weekly Thursday 'Hot Gall Bladder' list from July 2018 and this allowed the department to roll out the 'Hot Gall Bladder' service [Figure 1] with the help of the EGSs and on-site availability of the senior upper gastrointestinal surgeon (>10 year consultant experience) for advise and expertise, if required. This theatre list was run on a rolling 1:6 rota participated also by the two other non-EGSs.
Figure 1: Hot gallbladder pathway

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A dedicated referral form [Figure 2] was designed for the study that needed to be completed by the admitting team and submitted to the secretary's office that was governed by two surgical care practitioners. The deadline for submission was 12 noon every Tuesday allowing the 'operating surgeon for the week' time for review and decision on the operating Thursday list. The consent form used by the EGSs was the same as for delayed LC.
Figure 2: Dedicated booking form

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The data that were collected was prospectively entered into a secure online database (snapsurveys. com) ran by the trust audit department and included: Patient demographics, indications for surgery, reason for rejection, previous admissions, ASA grade, operative duration and difficulty, intra and post-operative complications, hospital stay (total and post-operative) and 30-day re-admissions. The data were analysed using standard statistical methods.

Nassar grading system was used to describe the degree of difficulty in performing the LC with grade 1 being the least and grade 4 being the most difficult based on the operative findings.[20]


  Results Top


Between 2018 (July) to 2019 (June), 299 laparoscopic cholecystectomies were performed at our DGH of the 299, 86 (29%) were performed in the 'Hot Gall Bladder List'.

143 patients were referred to the HGS with evidence of gallstone diseases. 86 (68%) were considered suitable and the remaining 57 (40%) were rejected for the hot gallbladder list. Of the 86, 70% (60) were women and the median age, ASA and body mass index (BMI) was 54 years, II and 27 respectively [Table 1]. Thirty-seven percent (21) of rejections (57) were due to patients' symptoms being more than 7 days in patients with acute cholecystitis [Table 2].
Table 1: Patient demographics

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Table 2: Rejected cases

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On ultrasonography, 36 patients had gall bladder wall thickness ranging between 4 and 20 mm and the remaining 50 patients had normal wall thickness. Eight patients underwent pre-operative ERCP due to abnormal liver function tests and USS and MRCP findings of dilated biliary tree/stones in the biliary tree and subsequently went for surgical intervention.

Eighty-six included 46 (53%), 19 (22%), 19 (22%) and 2 (3%) patients presenting with acute calculus cholecystitis, gallstone pancreatitis, biliary colic and acalculus cholecystitis, respectively.

The median number of previous admissions was 2 (1-4), Eighty-six patients had single/multiple previous admissions due to their gall bladder diseases that resulted in them spending extra 204-bed days in the hospital [Table 3].
Table 3: Previous admissions (days)

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Eighty-five (99%) patients underwent successful LC and a single patient had conversion to an open procedure. 26 (30%) and 60 (70%) patients had their gall bladder surgery between 3 and 7 days and between 2 and 3 days of their presentation, respectively [Table 4]. Median grade of surgical difficulty [Table 5] was 2 (1–4) and duration of surgery was 68 (30–240) min. Technique adapted for grade-4 difficult cases has previously been described and the author would like to refer readers to the published article.[21] Abdominal drain in the right upper quadrant was required in 13 patients. The median total and post-operative length of stay was 2 (1–18) days and 0 (0–13) days, respectively. Eight (9%) patients required input from senior surgeons for safe operative intervention. There were no intra-operative complications and 2 (2%) patients had 30-day readmissions. One was due to post-operative collection that recovered uneventfully on conservative management. The second patient was due to pancreatitis, subsequent imaging was clear and thus required no further intervention.
Table 4: Time of intervention from onset of symptoms

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Table 5: Degree of operative difficulty

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Histology confirmed acute on chronic cholecystitis in 20 and chronic cholecystitis in the remaining 66 patients.


  Discussions Top


Hot GB surgery for acute gallstone disease in the past was deferred for concerns of higher conversion and increased morbidity, however, all recent evidence support their early intervention.[16] Delayed intervention puts one-third of patients at increased risk of recurrent acute episodes, repeated admissions and severe complications, further delaying their elective intervention. The practice of ELC for acute gallstone disease has been extremely variable within the NHS. Variation in the workforce, organisational and operational problems, lack of logistic support have been identified as factors responsible for poor uptake of early interventions.[17] The lack of theatre space and availability of appropriately trained workforce has been the most important deterrents for ELC.[3] The RCS in October 2016 set a standard that aimed for 80% of eligible, admitted patients to have their gall bladder surgery within 8 days of presentation at the hospital, in support of the NICE guidance.[19]

Evidence of improved cancer surgery outcomes based on the centralisation of upper gastrointestinal and hepatopancreatobiliary services to specialised units with large catchment areas has resulted in the lack of the adequate number of experienced upper gastrointestinal/HPB surgeons in the not designated upper gastrointestinal/HPB cancer hospitals. This organisational change designed to enhance outcome for one group of patients (cancer sufferers) has led to disadvantaging other groups of patients although patients with more severe benign disease presentations are being transferred to these specialised centres for their improved outcome.[20]

Bile-duct injury is the most dreaded complication during cholecystectomy, which can be fatal.[22] The main reason for conversion in ELC is the inflammation that obscures the view of the Calot's triangle.[23] whereas in delayed LC it is the fibrotic adhesions in the Calot's triangle that raises concerns of safe surgery.[24]

Experience of the operating surgeon for ELC is vital as the surgery for ELC is more complex and conversion rates higher in acute cholecystitis than in uncomplicated symptomatic gallstone disease. ELC often requires technical modification like higher gall bladder decompression than in a delayed cholecystectomy.[25] Thus, LC when performed by upper GI surgeons have lower conversions and shorter hospital stay compared to those performed by non-upper GI surgeons and evidence supports ELC to be performed in units with the ready availability of appropriate surgical expertise and adequate laparoscopic experience.[15]

This is a DGH that undertakes between 295 and 300 laparoscopic cholecystectomies a year. ELC was performed in <10% of cases before 2018. 'Hot Gall Bladder Service' was only implemented after the acquisition of a dedicated weekly theatre list and definite availability of the upper gastrointestinal surgeon for advice and support in theatres, if required. This allowed 29% of cases to be performed as ELC and there is an opportunity for acquisition of more dedicated weekly theatre slots in the future with further scope of improvement of this figure.

Ninety-nine percent of patients had successful laparoscopic intervention with no record of intra-operative and post-operative complications and there were low acceptable 30-day readmissions. 84% patients were graded as ≤2 as regards operative difficulty, conversion to open was required only in a single patient (1%) and input from a senior upper gastrointestinal surgeon was required in 9% of cases. Support from the senior upper gastrointestinal surgeon was invaluable as this helped learning, improve the technical skills and confidence of the EGS for better patient safety and care. Gallbladder bed collections that is reported in 14% of patients post-cholecystectomy[2] was found only in a single patient (1%) requiring readmission with an uneventful recovery. The median post-operative stay was 0 day. 70% of our patients had required previous hospital admissions related to their gall stone disease requiring 204 hospital bed day admissions. The average cost for the NHS for a day in hospital amounts to ≤300, thus, costing the trust an unnecessary extra ≤61,200 only for this period.

Meta-analysis in 2010 stated that LC is appropriate up to 7 days after the onset of symptoms.[15] Our data showed 37% of patients were rejected as they fell beyond the 7-day cut-off point. Limited theatre access is responsible and we believe the availability of more dedicated theatre slots would help to improve this figure. Sixteen percent patients were rejected awaiting imaging. Once again better and easy access to advanced imaging like MRCP would address this limitation. Ten percent of patients who were refused due to poor documentation would improve with education and training of the trainees and better communication. Nine percent of patients were rejected for higher BMI. This is an individual surgeon choice and an area that would improve with increased exposure and surgical experience in dealing with patients of higher BMI with acute presentations.


  Conclusion Top


This prospective observational study despite its limitations of being small with a slightly high rejection rate and not being randomised, thus, lacking comparison with a DLC group still highlighted the positives and benefits and once again challenges the previous erroneous myths of ELC. The study concludes in the current climate of NHS financial crunch, COVID pandemic and pressure on inpatient beds: Safe, efficient and cost-effective 'Hot Gall Bladder Service' can be provided by the EGSs with input from senior upper GI/HPB surgeons (when required) with acceptable morbidity and a satisfactory outcome and support its wider implementation and acceptance in the NHS.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Royal College of Surgeons of England. Association of Surgeons of Great Britain and Ireland Emergency General Surgery. London: RCS; 2013.  Back to cited text no. 1
    
2.
National Institute of Health and Care Excellence. Gallstone Disease: Diagnosis and Management: Clinical Guideline; 2014. Available from: https://www.nice.org.uk/guidance/cg188/chapter/1. [Last accessed on 2018 May 30].  Back to cited text no. 2
    
3.
Saad UK, Jun YS, Nazli M, Aikaterini P, Abdullah M, Waterland PW, et al. Emergency laparoscopic cholecystectomy: Is dedicated Hot gall bladder list Cost effective? J Ayub Med Coll Abbotabad 2019;31:3-7.  Back to cited text no. 3
    
4.
Gurusamy KS, Nagendran M, Davidson BR. Early versus delayed laparoscopic cholecystectomy for acute gallstone pancreatitis. Cochrane Database Syst Rev 2013;(9):CD010326. 10.1002/14651858.CD010326.pub2.  Back to cited text no. 4
    
5.
Gutt CN, Encke J, Köninger J, Harnoss JC, Weigand K, Kipfmüller K, et al. Acute cholecystitis: Early versus delayed cholecystectomy, a multicenter randomized trial (ACDC study, NCT00447304). Ann Surg 2013;258:385-93.  Back to cited text no. 5
    
6.
Zhou MW, Gu XD, Xiang JB, Chen ZY. Comparison of clinical safety and outcomes of early versus delayed laparoscopic cholecystectomy for acute cholecystitis: A meta-analysis. Scientific World J 2014;2014:274516. doi: 10.1155/2014/274516. Epub 2014 Jul 14.  Back to cited text no. 6
    
7.
The Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland: The Provision of Services for Upper Gastrointestinal Services; April 2016. Available from: https://www.augis.org/wp-content/uploads/2016/06/Provision-of-Services-June-2016.pdf.[Last accessed on 2020 Oct 19].  Back to cited text no. 7
    
8.
Cameron IC, Chadwick C, Phillips J, Johnson AG. Management of acute cholecystitis in UK hospitals: Time for a change. Postgrad Med J 2004;80:292-4.  Back to cited text no. 8
    
9.
Feliu X, Targarona EM, García-Agustí A, Pey A, Carrillo A, Lacy AM, et al. The development of laparoscopic surgery in Spain. Dig Surg 2004;21:421-5.  Back to cited text no. 9
    
10.
Yamashita Y, Takada T, Hirata K. A survey of the timing and approach to the surgical management of patients with acute cholecystitis in Japanese hospitals. J Hepatobiliary Pancreat Surg 2006;13:409-15.  Back to cited text no. 10
    
11.
Senapati PS, Bhattarcharya D, Harinath G, Ammori BJ. A survey of the timing and approach to the surgical management of cholelithiasis in patients with acute biliary pancreatitis and acute cholecystitis in the UK. Ann R Coll Surg Engl 2003;85:306-12.  Back to cited text no. 11
    
12.
Murray AC, Markar S, Mackenzie H, Baser O, Wiggins T, Askari A, et al. An observational study of the timing of surgery, use of laparoscopy and outcomes for acute cholecystitis in the USA and UK. Surg Endosc 2018;32:3055-63.  Back to cited text no. 12
    
13.
Wiggins T, Markar SR, MacKenzie H, Faiz O, Mukherjee D, Khoo DE, et al. Optimum timing of emergency cholecystectomy for acute cholecystitis in England: Population-based cohort study. Surg Endosc 2019;33:2495-502.  Back to cited text no. 13
    
14.
Royal College of Surgeons of England. Reshaping Surgical Service; Principles for Change. London: RCS; 2013.  Back to cited text no. 14
    
15.
Gurusamy K, Samraj K, Gluud C, Wilson E, Davidson BR. Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg 2010;97:141-50.  Back to cited text no. 15
    
16.
Lu J, Cheng Y, Xiong XZ, Lin YX, Wu SJ, Cheng NS, et al. Two-stage vs. single-stage management for concomitant gallstones and common bile duct stones. World J Gastroenterol 2012;18:3156-66.  Back to cited text no. 16
    
17.
Kerwat D, Zargaran A, Bharamgoudar R, Arif N, Bello G, Sharma B, et al. Early laparoscopic cholecystectomy is more cost-effective than delayed laparoscopic cholecystectomy in the treatment of acute cholecystitis. Clinicoecon Outcomes Res 2018;10:119-25.  Back to cited text no. 17
    
18.
Bokhari S, Walsh U, Qurashi K, Liasis L, Watfah J, Sen M, et al. Impact of a dedicated emergency surgical unit on early laparoscopic cholecystectomy for acute cholecystitis. Ann R Coll Surg Engl 2016;98:107-15.  Back to cited text no. 18
    
19.
Gurusamy KS, Samraj K. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Cochrane Database Syst Rev 2006;(4):CD005440.  Back to cited text no. 19
    
20.
Siriwardena AK. Centralisation of upper gastrointestinal cancer surgery. Ann R Coll Surg Engl 2007;89:335-6.  Back to cited text no. 20
    
21.
Harilingam MR, Shrestha AK, Basu S. Laparoscopic modified subtotal cholecystectomy for difficult gall bladders: A single-centre experience. J Minim Access Surg 2016;12:325-9.  Back to cited text no. 21
    
22.
Sicklick JK, Camp MS, Lillemoe KD, Melton GB, Yeo CJ, Campbell KA, et al. Surgical management of bile duct injuries sustained during laparoscopic cholecystectomy: Perioperative results in 200 patients. Ann Surg 2005;241:786-92.  Back to cited text no. 22
    
23.
Peng WK, Sheikh Z, Nixon SJ, Paterson-Brown S. Role of laparoscopic cholecystectomy in the early management of acute gallbladder disease. Br J Surg 2005;92:586-91.  Back to cited text no. 23
    
24.
Lo CM, Liu CL, Fan ST, Lai EC, Wong J. Prospective randomized study of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Ann Surg 1998;227:461-7.  Back to cited text no. 24
    
25.
Johansson M, Thune A, Lundell L. Management of acute cholecystitis in the laparoscopic era: Results of a prospective, randomized clinical trial. J Gastrointest Surg 2003;7:642-5.  Back to cited text no. 25
    


    Figures

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  [Table 1], [Table 2], [Table 3], [Table 4], [Table 5]



 

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2004 Journal of Minimal Access Surgery
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