Users Online : 2308 About us |  Subscribe |  e-Alerts  | Feedback | Login   
Journal of Minimal Access Surgery Current Issue | Archives | Ahead Of Print Journal of Minimal Access Surgery
           Print this page Email this page   Small font sizeDefault font sizeIncrease font size 
  Search
 
  
 ¤   Similar in PUBMED
 ¤Related articles
 ¤   Article in PDF (1,630 KB)
 ¤   Citation Manager
 ¤   Access Statistics
 ¤   Reader Comments
 ¤   Email Alert *
 ¤   Add to My List *
* Registration required (free)  


 ¤  Abstract
 ¤ Introduction
 ¤ Case Report
 ¤  References
 ¤  Article Figures

 Article Access Statistics
    Viewed790    
    Printed12    
    Emailed0    
    PDF Downloaded24    
    Comments [Add]    

Recommend this journal

 


 
 Table of Contents     
IMAGES IN LAPAROSCOPY
Year : 2021  |  Volume : 17  |  Issue : 3  |  Page : 418-420
 

A case of Endometrioid endometrial adenocarcinoma with synchronous low-grade Appendiceal mucinous neoplasm and Pseudomyxoma peritonei


Department of Gynaec Endoscopy, Womens Hospital, Mumbai, Maharashtra, India

Date of Submission15-Aug-2020
Date of Acceptance12-Oct-2020
Date of Web Publication03-Feb-2021

Correspondence Address:
Dr. Sharda Arvind
Women's Hospital, 674, 16th Cross Road, Behind Khar Gymkhana, Khar West, Mumbai - 400 052, Maharashtra
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jmas.JMAS_177_20

Rights and Permissions

 ¤ Abstract 

Pseudomyxoma peritonei (PMP) is a rare condition usually associated with ruptured low-grade mucinous neoplasm of the appendix. Rarely, PMP can originate from mucinous adenocarcinoma of the ovary. However, the coexistence of adenocarcinoma of the endometrium and appendiceal mucinous neoplasm has not been reported. We present the case of a post-menopausal woman with endometrioid endometrial adenocarcinoma with unexpected low-grade appendiceal mucinous neoplasm and PMP.


Keywords: Appendiceal mucinous neoplasm, pseudomyxoma peritonei, synchronous tumours


How to cite this article:
Raje S, Arvind S, Rao G. A case of Endometrioid endometrial adenocarcinoma with synchronous low-grade Appendiceal mucinous neoplasm and Pseudomyxoma peritonei. J Min Access Surg 2021;17:418-20

How to cite this URL:
Raje S, Arvind S, Rao G. A case of Endometrioid endometrial adenocarcinoma with synchronous low-grade Appendiceal mucinous neoplasm and Pseudomyxoma peritonei. J Min Access Surg [serial online] 2021 [cited 2021 Jul 25];17:418-20. Available from: https://www.journalofmas.com/text.asp?2021/17/3/418/308672



 ¤ Introduction Top


Pseudomyxoma peritonei (PMP) is the intraperitoneal accumulation of mucus due to ruptured mucinous neoplasm of the appendix characterised by redistribution phenomenon. Rarely, PMP may develop from mucinous neoplasms of other organs such as ovary, colon, urachus and pancreas.[1] PMP is classified according to the histology of peritoneal disease as mucin without epithelial cells, low-grade mucinous carcinoma peritonei, high-grade mucinous carcinoma peritonei and high-grade mucinous carcinoma peritonei with signet ring cells.[1]

The incidence of primary appendicular tumour is <2% with 0.3% prevalence of mucinous neoplasms in surgically removed specimens.[2] The incidence is higher in females with a median age of 60 years. The most common symptoms are pain in the right iliac region and palpable abdominal mass.[3] In 25% of cases, patients are asymptomatic and a diagnosis of appendiceal mucinous neoplasm is incidental during gynaecological screening.[2] The appendiceal mucinous neoplasm has a spectrum ranging from adenoma to adenocarcinoma. Low-grade appendiceal mucinous neoplasms (LAMNs) are mucinous neoplasms with low-grade cytological atypia with any of the following features: loss of muscularis mucosae, fibrosis of submucosa, presence of acellular mucin inside the wall and pushing invasion without causing infiltration of the wall, appendiceal rupture and presence of extra-appendiceal mucin or cells.[2],[3]

The most important factor affecting the treatment and survival of patients with appendiceal mucinous tumours is development of PMP.

Appendiceal mucinous tumours have been reported to coexist with mucinous ovarian epithelial tumours. However, the coexistence of adenocarcinoma of endometrium and appendiceal mucinous neoplasm has not been reported.

We present the case of a post-menopausal woman with endometrioid endometrial adenocarcinoma with unexpected LAMN and PMP.


 ¤ Case Report Top


An 82-year-old, P4 L4, woman presented with post-menopausal bleeding. Magnetic resonance imaging showed a bulky uterus with a thickened endometrium with focal areas of breach in the junctional zone and intramyometrial extension, suggestive of carcinoma of the endometrium. Both ovaries were atrophic. Mild ascites was seen with no pelvic lymphadenopathy [Figure 1].
Figure 1: Magnetic resonance imaging image

Click here to view


Hysteroscopy showed vascular growth arising from the right anterolateral wall of the uterus. Endometrial biopsy revealed well-differentiated adenocarcinoma.

Intraoperatively, a mucinous jelly-like material was seen in the pelvis [Figure 2]. The uterus was normal in size. Bilateral  Fallopian tube More Detailss and ovaries were atrophic. Friable growth arising from the appendix with mucinous deposits was seen [Figure 3]. Frozen section of the appendicular mass contained acellular mucinous material.
Figure 2: Pseudomyxoma peritonei

Click here to view
Figure 3: Perforated appendicular mass

Click here to view


We performed total laparoscopic hysterectomy with bilateral salpingo-oophorectomy and bilateral pelvic lymph node dissection and appendicectomy. Multiple peritoneal and omental biopsies were taken.

Histopathology revealed moderately differentiated endometrioid adenocarcinoma of the endometrium, FIGO Stage IB (The International Federation of Gynecology and Obstetrics) with a synchronously occurring low-grade mucinous neoplasm of the appendix showing a perforation and PMP [Figure 4].
Figure 4: H and E images: (a) Endometrioid adenocarcinoma. (b) Pseudomyxoma peritonei. (c) Ruptured appendicular neoplasm. (d) Low.grade mucinous neoplasm of the appendix

Click here to view


She was referred to an oncosurgeon for further management where she was advised cytoreductive surgery with hyperthermic intraperitoneal chemotherapy.

Acknowledgement

The authors would like to acknowledge Dr Maria Alina DeSouza (Consultant Pathologist, S.L.Raheja Hospital, Mumbai), for providing the H & E images.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initial will not be published, and due efforts will be made to conceal identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
 ¤ References Top

1.
Carr NJ, Cecil TD, Mohamed F, Sobin LH, Sugarbaker PH, González-Moreno S, et al. A consensus for classification and pathologic reporting of pseudomyxoma peritonei and associated appendiceal neoplasia: The results of the peritoneal surface oncology group international (PSOGI) modified Delphi process. Am J Surg Pathol 2016;40:14-26.  Back to cited text no. 1
    
2.
Vavinskaya V, Baumgartner JM, Ko A, Saenz CC, Valasek MA. Low-grade appendiceal mucinous neoplasm involving the endometrium and presenting with mucinous vaginal discharge. Case Rep Obstet Gynecol 2016;2016.  Back to cited text no. 2
    
3.
Gündogar Ö, Kimiloglu E, Komut N, Cin M, Bektas S, Gönüllü D, et al. Evaluation of appendiceal mucinous neoplasms with a new classification system and literature review. Turk J Gastroenterol 2018;29:533-42.  Back to cited text no. 3
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

Top
Print this article  Email this article
 

    

© 2004 Journal of Minimal Access Surgery
Published by Wolters Kluwer - Medknow
Online since 15th August '04