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Year : 2006  |  Volume : 2  |  Issue : 3  |  Page : 151-154

Hernia recurrence as a problem of biology and collagen

1 Department of Surgery, University Hospital of the RWTH Aachen, Aachen, Germany
2 Department of Nephrology and Clinical Immunology, University Hospital of the RWTH Aachen, Aachen, Germany

Correspondence Address:
Uwe Klinge
Department of Surgery, University Hospital of the RWTH Aachen, Pauwelsstraße 30, 52074 Aachen
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0972-9941.27729

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Usually an abdominal wall hernia is regarded as a mechanical problem with a local defect which has to be closed by technical means. Despite the introduction of several therapeutic improvements, recurrent hernias still appear in 10-15%. Therefore, reasons for a recurrence are discussed in a more fundamental way. It is assumed that a failure mainly depends on the quality of the repair. Correspondingly, in principle, the close causal relationship between the technical component and its failure during time is reflected by an s-shaped outcome curve. In contrast, the configuration of the outcome curve changes markedly if a breakdown is caused by numerous components. Then, the superposition of all incidence curves inevitably leads to a linear decline of the outcome curve without any s-shaped deformation. Regarding outcome curves after hernia repair, the cumulative incidences for recurrences of both incisional and inguinal hernia show a linear rise over years. Considering the configuration of outcome curves of patients with hernia disease, it may therefore be insufficient to explain a recurrence just by a failing technical repair. Rather, biological reasons should be suspected, such as a defective wound healing with impaired scarring process. Recent molecular-biological findings provide increasing evidence of underlying biochemical alterations in patients with recurrent hernia. Until predicting markers to identify patients with an impaired wound healing are available and considering the formation of insufficient scar as the underlying disease, the consequences for every surgical repair should be a supplementary reinforcement with nonabsorbable alloplastic nets as flat meshes with an extensive overlap.

Keywords: Biology, collagen, hernia, network, recurrence, wound healing

How to cite this article:
Klinge U, Binnebosel M, Rosch R, Mertens P. Hernia recurrence as a problem of biology and collagen. J Min Access Surg 2006;2:151-4

How to cite this URL:
Klinge U, Binnebosel M, Rosch R, Mertens P. Hernia recurrence as a problem of biology and collagen. J Min Access Surg [serial online] 2006 [cited 2022 Sep 27];2:151-4. Available from:

Who or what is to blame for a recurrent hernia? The question whether the patient or the surgeon is responsible for a recurrence is of fundamental relevance not only in hernia repair but also in other therapeutic approaches, as in oncological surgery. Considering recurrence as a problem of biology and collagens, one should not neglect technical failures directly leading to a poor outcome.[1],[2] However, regarding the persisting rates of operations for recurrent hernia of 10-15% worldwide despite all therapeutic improvements, a more fundamental pathology for hernia formation must be considered.[3],[4],[5],[6]

  Hernia recurrence as a technical problem Top

Usually, an abdominal wall hernia is regarded as a mechanical problem with a local defect which has to be closed technically, either by sutures or, in modern times, with meshes.[7],[8],[9] In the long history of hernia repair, even the most experienced surgeon, irrespective of the utilized technique, has to face recurrences that have been created by him and correspondingly have to be regarded as his personal technical failure. Thus, why is it obviously impossible in hernia surgery to make mechanical repair with success rates being expected similar to those for engineering, without saying?

If a defective element in an apparatus is repaired by a technician, it is expected that it will work for some time, eventually breaking down again after a certain period of time. It is assumed that the occurrence of a failure just depends upon the quality of repair. For a large cohort of machines, the incidence of a breakdown of this element should represent a time-related maximum, when the repair stops working and correspondingly lead to an s-shaped 'survival'-curve. In accordance, focusing on the breakdown of cars caused by one single component there results in an s-shaped survival curve with a maximum incidence after some years [Figure - 1]. The close causal relationship between one technical component and its failure is reflected by s-shaped survival curve. Interestingly, the configuration of the survival curve changes markedly if a breakdown were to be caused by one of the numerous components of a car with incidences rising constantly over a period of time. It is the superposition of all survival curves that inevitably leads to a linear decline of the survival curve without any s-shaped deformation [Figure - 2], disguising the causal impact of any one specified component.

What are the consequences for surgeons? Analogously, a close causal relationship between technique and failure may be expected only if an s-shaped survival curve is observed. If the recurrence is considered just as a technical failure, this should occur either soon or with a certain delay, but in any case the outcome curve should reveal an s-shaped configuration. However, this contradicts the actual proportions. In contrast, in incisional and inguinal hernia formation.[5],[10],[11] the cumulative incidences show a linear rise over years without any s-shaped deformation. This course is in contradiction to any significant direct causal relationship between technique and recurrence. Instead, an underlying multifactorial process has to be suggested. Furthermore, because most of the recurrences occur after 1 year within the linear rise of the cumulative incidences, a multifactorial process seems to be far more important than any accusable factor of the early postoperative course. Comparing the results of mesh repair with suture repair, it cannot even be concluded that mesh therapies in particular may only lead to a delayed manifestation of the recurrence in the long run instead of preventing them. For the latter case, it should be expected that the cumulative incidences should end in a final plateau. As a consequence, the consideration of recurrence as a result of a multifactorial and multi-causal process raises questions which indicate that complex system other than the operation procedure itself may serve as an explanation for this outcome.

  Recurrence as a problem of biology and collagens Top

Every technique used for hernia repair has to rely on formation of sufficient scar tissue. The scarring process is a form of defective healing replacing physiological tissues by fibrotic tissue abundant in fibroblasts and collagens. It results from a complex network with interactions of countless mediators of wound healing and an intensive cross-talk with cells, in particular with macrophages. Because of the long half-life of the collagens in comparison to all the various growth factors and cytokines, the collagens may reflect best the altered regulation of the scarring process, though changes in further components of the extracellular matrix have been observed, such as in the expression of the matrix metalloproteinase 2 (MMP-2) [Figure - 3].[12],[13],[14],[15],[16] Therefore, it is not surprising that a decreased collagen type I/III ratio could be verified in adult patients with groin hernia (and in the scar of patients with recurrent hernia.[13],[14] Whereas collagen type I is characteristic for mature scars or fascial tissue, the collagen type III represents the mechanically instable, less cross-linked collagen synthesized during the early days of wound healing. Correspondingly, in patients with recurrent hernias, there seems to be an impaired maturing of their scar tissue, which is not able to close the hernia gap or fix the mesh in place for long. As a consequence, a recurrence may develop either through a scar or at the border of a synthetic mesh through its scarry fixation.[17] Interestingly, an altered function could be detected even in vitro in macrophages' free cultures of fibroblasts from patients with recurrent hernia, indicating an inherent and genetic and thereby probably systemic problem.[18] A comprehensive overview of the role of collagens in hernia disease is given elsewhere.[19]

The impaired quality of the scar of patients with recurrences not only explains the outcome curves [Figure - 4] but also explains the fact that exogenous factors such as smoking could be identified as major risk factors.[20] Furthermore, it explains the high frequency of incisional hernia in patients with abdominal aortic aneurysm and their proven defect of the collagen metabolism.[21],[22],[23] It explains as well the frequent development of recurrences, if not the entire scar, was reinforced and that the best technique sometimes fails even in the hands of experts.

  Technique or biology? It is both! Top

Patients with hernia disease and in particular those with an incisional hernia are likely predisposed for recurrent hernia formation. Unfortunately, until now we do not have any predicting markers to identify those with an impaired wound healing and scar formation. The most significant factor still is a patient's history of hernia repair with markedly elevated re-recurrence rates.

Whereas recurrent and incisional hernias following suture repair are most likely caused by a defective biology, nevertheless the recurrence following mesh repair may be regarded as a technical fault, at least in theory. Despite the disappointing results in the study of Flum,[10] it should be achievable to delay a recurrence life-long, if a sufficient overlap is provided. In consideration of the tensile strength of current mesh materials, it is the extent of overlap which determines whether and when a recurrence may appear. In accordance, until now almost all recurrences manifest at the border of a dislocated, shrunken or undersized mesh, almost never through a mesh itself. Therefore, in principle it really should be possible to prevent recurrences by mesh repair, though until now this could not been proven by epidemiological data. However, there are a lot of personal series with excellent recurrence rates, underlining the efficacy of mesh repairs. A reason for this discrepancy of the results may be the neglect of the problem of overlap, either for anatomical reasons or for given limitations of some techniques. Focusing on a sufficient reinforcement of healthy tissue in all directions should improve recurrence rates.

  Conclusion Top

It is the consideration of an insufficient scar formation, at least in patients with recurrent hernia disease, that requires a supplementary reinforcement with nonabsorbable alloplastic nets as flat meshes with an extensive overlap; as a consequence, suture repair should be restricted to those cases in which a previous technical failure is likely, e.g., trocar hernia with missed fascia closure. Taking into consideration all patients with primary hernia, the experiences of the past decades with suture repairs indicate that we should expect 15-20% to develop a recurrent hernia. It will depend on the long-term biocompatibility of our mesh materials whether it is justified to apply a mesh repair to all of the patients or to restrict it for selected patients at risk. Future perspective may provide further possibilities to improve scar quality itself, e.g., by biological active meshes.

  References Top

1.Conze J, Prescher A, Klinge U, Saklak M, Schumpelick V. Pitfalls in retromuscular mesh repair for incisional hernia: The importance of the "fatty triangle". Hernia 2004;8:255-9.  Back to cited text no. 1  [PUBMED]  
2.Israelsson LA, Smedberg S, Montgomery A, Nordin P, Spangen L. Incisional hernia repair in Sweden 2002. Hernia 2006;10:258-61.  Back to cited text no. 2  [PUBMED]  
3.Conze J, Klinge U, Schumpelick V. Incisional hernia. Chirurg 2005;76:897-909.  Back to cited text no. 3  [PUBMED]  [FULLTEXT]
4.Amid PK, Lichtenstein IL. Retromuscular alloplasty of large scar hernias: A simple staple attachment technique. Chirurg 1996;67:648-52.  Back to cited text no. 4  [PUBMED]  
5.Schumpelick V, Klinge U, Welty G, Klosterhalfen B. Meshes within the abdominal wall. Chirurg 1999;70:876-87.  Back to cited text no. 5    
6.Eid GM, Prince JM, Mattar SG, Hamad G, Ikrammudin S, Schauer PR. Medium-term follow-up confirms the safety and durability of laparoscopic ventral hernia repair with PTFE. Surgery 2003;134:599-604.  Back to cited text no. 6  [PUBMED]  [FULLTEXT]
7.Toy FK, Bailey RW, Carey S, Chappuis CW, Gagner M, Josephs LG, et al . Prospective, multicenter study of laparoscopic ventral hernioplasty. Preliminary results. Surg Endosc 1998;12:955-9.  Back to cited text no. 7    
8.Trupka AW, Hallfeldt KK, Schmidbauer S, Schweiberer L. Management of complicated incisional hernias with underlay-technique implanted polypropylene mesh. An effective technique in French hernia surgery. Chirurg 1998;69:766-72.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]
9.Langer C, Liersch T, Kley C, Flosman M, Suss M, Siemer A, et al . Twenty-five years of experience in incisional hernia surgery. A comparative retrospective study of 432 incisional hernia repairs. Chirurg 2003;74:638-45.  Back to cited text no. 9    
10.Flum DR, Fisher N, Thompson J, Marcus-Smith M, Florence M, Pellegrini CA. Washington State's approach to variability in surgical processes/outcomes: Surgical Clinical Outcomes Assessment Program (SCOAP). Surgery 2005;138:821-8.  Back to cited text no. 10  [PUBMED]  [FULLTEXT]
11.Junge K, Rosch R, Klinge U, Schwab R, Peiper CH, Binnebosel M, et al . Risk factors related to recurrence in inguinal hernia repair: A retrospective analysis. Hernia 2006;10:309-15.  Back to cited text no. 11    
12.Junqueira LC, Cossermelli W, Brentani R. Differential staining of collagens type I, II and III by Sirius Red and polarization microscopy. Arch Histol Jpn 1978;41:267-74.  Back to cited text no. 12    
13.Junge K, Klinge U, Rosch R, Mertens PR, Kirch J, Klosterhalfen B, et al . Decreased collagen type I/III ratio in patients with recurring hernia after implantation of alloplastic prostheses. Langenbecks Arch Surg 2004;389:17-22.  Back to cited text no. 13    
14.Rosch R, Junge K, Knops M, Lynen P, Klinge U, Schumpelick V. Analysis of collagen-interacting proteins in patients with incisional hernias. Langenbecks Arch Surg 2003;387:427-32.  Back to cited text no. 14    
15.Rosch R, Lynen-Jansen P, Junge K, Knops M, Klosterhalfen B, Klinge U, et al . Biomaterial-dependent MMP-2 expression in fibroblasts from patients with recurrent incisional hernias. Hernia 2006;1-6.  Back to cited text no. 15    
16.Inkinen K, Turakainen H, Wolff H, Ravanti L, Kahari VM, Ahonen J. Expression and activity of matrix metalloproteinase-2 and -9 in experimental granulation tissue. APMIS 2000;108:318-28.  Back to cited text no. 16    
17.Conze J, Rosch R, Klinge U, Weiss C, Anurov M, Titkowa S, et al . Polypropylene in the intra-abdominal position: Influence of pore size and surface area. Hernia 2004;8:365-72.  Back to cited text no. 17    
18.Si Z, Bhardwaj R, Rosch R, Mertens PR, Klosterhalfen B, Klinge U. Impaired balance of type I and type III procollagen mRNA in cultured fibroblasts of patients with incisional hernia. Surgery 2002;131:324-31.  Back to cited text no. 18    
19.Read RC. The fault(s) of the patient: scar reaction and biological recurrence. In Meshes: Benefits and risks. Schumpelick, Nyhus: Springer-Verlag; 2004. p. 479.  Back to cited text no. 19    
20.Sorensen LT, Hemmingsen UB, Kirkeby LT, Kallehave F, Jorgensen LN. Smoking is a risk factor for incisional hernia. Arch Surg 2005;140:119-23.  Back to cited text no. 20    
21.Claridge MW, Hobbs SD, Quick CR, Day NE, Bradbury AW, Wilmink AB. ACE inhibitors increase type III collagen synthesis: A potential explanation for reduction in acute vascular events by ACE inhibitors. Eur J Vasc Endovasc Surg 2004;28:67-70.  Back to cited text no. 21    
22.Rizzo RJ, McCarthy WJ, Dixit SN, Lilly MP, Shively VP, Flinn WR, et al . Collagen types and matrix protein content in human abdominal aortic aneurysms. J Vasc Surg 1989;10:365-73.  Back to cited text no. 22    
23.Powell JT, Adamson J, MacSweeney ST, Greenhalgh RM, Humphries SE, Henney A. Genetic variants of collagen III and abdominal aortic aneurysm. Eur J Vasc Surg 1991;5:145-8.  Back to cited text no. 23    


[Figure - 1], [Figure - 2], [Figure - 3], [Figure - 4]

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