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ORIGINAL ARTICLE
Ahead of Print

Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma


1 Department of General Surgery, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China
2 Department of Colorectal Surgery, Second Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China

Correspondence Address:
Chungen Xing,
Department of Colorectal Surgery, Second Hospital Affiliated to Soochow University, 1055 Sanxiang Road, Suzhou 215004 Jiangsu Province
China
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jmas.JMAS_217_17

PMID: 29483379

Objective: The objective of this study is to investigate the effects of laparoscopic and open operation on serum and peritoneal inflammatory mediators in patients with right colon carcinoma. Patients and Methods: A total of 100 patients were randomly divided into laparoscopic group (n = 50) and open group (n = 50). The age, sex, operation time, operation blood loss, post-operative Dukes stage, time to first passage of flatus and post-operative hospital stay were recorded. The levels of hypersensitive C reactive protein (hsCRP) and tumour necrosis factor-α (TNF-α) in serum and abdominal exudate were measured by ELISA at the time of pre-operative 2 h and post-operative 6 h and 24 h. Results: There was no significant difference in age, sex, Dukes stage and pre-operative inflammatory mediators between the two groups (P > 0.05). The operation time, intraoperative blood loss, time to first passage of flatus and post-operative hospital stay were significantly better in laparoscopic group than those in open operation group. At 6 h and 24 h after operation, the levels of hsCRP and TNF-α in serum and abdominal exudate in laparoscopic group were significantly lower than those in open operation group. Conclusions: Laparoscopic surgery for the treatment of right colon carcinoma has the advantages of fewer traumas, less systemic and local inflammatory response, rapider post-operative recovery and shorter hospital stay. It is worthy of clinical application.


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2004 Journal of Minimal Access Surgery
Published by Wolters Kluwer - Medknow
Online since 15th August '04