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ORIGINAL ARTICLE
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Quality of life after nissen fundoplication in patients with gastroesophageal reflux disease: Comparison between long- and short-term follow-up


1 Department of Surgery, Catharina Hospital Eindhoven, 5623 EJ Eindhoven, The Netherlands
2 Department of Surgery, MUMC+; Department of Intensive Care, 6229 HX Maastricht, The Netherlands
3 Department of Surgery, MUMC+, 6229 HX Maastricht, The Netherlands

Correspondence Address:
JF Smulders,
Department of Surgery, Catharina Hospital Eindhoven Michelangelolaan 2, 5623 EJ Eindhoven
The Netherlands
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Source of Support: None, Conflict of Interest: None

Introduction: Nissen fundoplication is the golden standard for surgical treatment of gastroesophageal reflux disease (GERD). Numerous studies report excellent short-term results. However, data regarding long-term quality of life are lacking. The aim of this study is to investigate the long-term quality of life after Nissen fundoplication in patients with GERD and to compare this with the short-term results. Patients and Methods: We retrospectively analysed all patients who underwent laparoscopic Nissen fundoplication for GERD between January 2004 and January 2016. All patients received a validated GERD-Health-Related Quality of Life questionnaire by mail to assess post-operative quality of life. Maximum quality of life is represented by a score of 75. Secondary outcome measures were complications and recurrence rate. Results: One hundred and seventy-five (77.1%) of the 227 operated patients returned the questionnaire. The median follow-up was 3.7 (0.1–10.3) years. Mean age was 51.6 (range 15–85) and 72 patients were male. We report an excellent quality of life with a median total score of 70 (range 2–75). Re-operation rate was 13.6% (23/169); the re-operation was due to recurrent reflux in 12 patients and due to persistent dysphagia in 11 patients. 91.3% of the re-operations were performed within the first 5 years after surgery. Mortality rate was zero. Conclusion: We report a large series of single-centre, single-surgeon laparoscopic Nissen fundoplication. Despite the re-operation rate of 13.6%, we found excellent long-term symptomatic outcome. There was no difference between short- and long-term results.


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    -  Castelijns P S
    -  Ponten J E
    -  vd Poll M C
    -  Bouvy N D
    -  Smulders J F
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2004 Journal of Minimal Access Surgery
Published by Wolters Kluwer - Medknow
Online since 15th August '04