|Year : 2019 | Volume
| Issue : 4 | Page : 299-304
Laparoscopic total extraperitoneal inguinal hernia repair is safe and feasible in patients with continuation of antithrombotics
Chen-Hsun Ho1, Chia-Chang Wu1, Chao-Chuan Wu2, Yao-Chou Tsai3
1 Department of Urology, School of Medicine, College of Medicine; Department of Urology, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan
2 Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei, Taiwan
3 Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, Taipei; Department of Urology, Medical College, Tzu Chi University, Hualien, Taiwan
|Date of Submission||18-May-2018|
|Date of Acceptance||10-Jul-2018|
|Date of Web Publication||10-Sep-2019|
Department of Surgery, Taipei Tzuchi Hospital, The Buddhist Tzu Chi Medical Foundation, 289 Jianguo Road, Xindian, Taipei
Source of Support: None, Conflict of Interest: None
Aims: We aimed to evaluate the safety and feasibility of laparoscopic total extraperitoneal (TEP) inguinal hernia repair in patients with the continuation of their antithrombotic agents.
Settings and Design: This was prospective cohort study.
Materials and Methods: A total of 115 patients who underwent TEP inguinal hernia repair between January 2015 and September 2016 were included in the analysis. Seventeen patients continued their antithrombotics (antithrombotic group); the other 98 had not been on antithrombotics (control group).
Statistical Analysis Used: The analysis was performed by using Mann–Whitney U-test, Chi-square or Fisher's exact test.
Results: The antithrombotic group had a greater mean age (65.9 ± 8.0 vs. 57.7 ± 13.6,P= 0.002) and higher prevalence of hypertension (64.7% vs. 33.7%,P= 0.015), cardiovascular diseases (64.7% vs. 7.1%,P < 0.001), atrial fibrillation (23.5% vs. 0,P < 0.001), ischaemic heart disease (35.3% vs. 0,P < 0.001) and the American Society of Anaesthesiologists ≥2 (94.1% vs. 81.6%,P= 0.005). The operation time for the antithrombotic group was longer than that of the control group (92.06 ± 32.81 min vs. 72.33 ± 20.99 min,P= 0.015). None experienced conversion to open surgery in either group. There was no difference in the post-operative complications (29.4% vs. 28.6%) and sero-haematoma formation (23.5% vs. 11.1%). The analgesic requirement, hospital stays (23.72 ± 7.74 vs. 22.35 ± 10.33 h) and the time for return to normal daily activity (3.56 ± 1.74 vs. 3.63 ± 1.90) were not statistically different between the two groups. None in either group experienced major cardiovascular events within 30 days.
Conclusions: Laparoscopic TEP inguinal hernia repair can be safely performed in patients with the continuation of their antithrombotic agents in experienced hands.
Keywords: Anticoagulant, antiplatelet, antithrombotic, inguinal hernia, laparoscopic
|How to cite this article:|
Ho CH, Wu CC, Wu CC, Tsai YC. Laparoscopic total extraperitoneal inguinal hernia repair is safe and feasible in patients with continuation of antithrombotics. J Min Access Surg 2019;15:299-304
|How to cite this URL:|
Ho CH, Wu CC, Wu CC, Tsai YC. Laparoscopic total extraperitoneal inguinal hernia repair is safe and feasible in patients with continuation of antithrombotics. J Min Access Surg [serial online] 2019 [cited 2019 Nov 14];15:299-304. Available from: http://www.journalofmas.com/text.asp?2019/15/4/299/238777
| ¤ Introduction|| |
Inguinal hernia is a common condition, and the incidence and the need for surgical repair significantly increase with age. While the elderly population has a high prevalence of cardiovascular diseases or unfavourable cardiovascular risk, it is not uncommon that an aged surgical candidate is taking antiplatelets or anticoagulants. Clinically, whether to withdraw or to continue the antithrombotic agents in the perioperative period of an elective surgery such as an inguinal hernia is often a dilemma. The decision must weigh individual's risk for thromboembolic events and the risk of bleeding related to the procedure.
While the discontinuation of antithrombotic medications decreases bleeding during the operation and postoperatively, it nevertheless carries a substantial risk of thromboembolic events, especially in high-risk patients. In a systematic review of 1868 patients on long-term oral anticoagulants undergoing a variety of invasive procedures, 29 (1.6%) thromboembolic events occurred, while the thromboembolic rate in those who remained on anticoagulant during their procedure was only 0.4%. It was shown that in patients taking low-dose aspirin for the secondary prevention of cardiovascular or cerebrovascular events, discontinuation increases the risk of ischaemic stroke or transient ischaemic accident by 40% compared with continuation of therapy. In addition, strokes occurring after antithrombotic withdrawal have a higher morbidity and mortality than strokes in patients who continue the medications., Acute coronary syndrome or stroke appears to cluster in the first one to 2 weeks after medication withdrawal.
Laparoscopic total extraperitoneal (TEP) repair has become an established minimally invasive approach for inguinal hernia. The literature review showed that the rate of bleeding in TEP was as low as 0.41%. Although the generally low bleeding risk, there is still concern about whether the extensive dissection of the pre-peritoneal space in patients with antithrombotics or coagulopathy leads to significant haemorrhage. Recent studies revealed that in patients undergoing antithrombotic therapy TEP hernia repair can be safely performed during discontinuation of the antithrombotics with or without heparin bridging therapy., However, in those high-risk patients who should not risk antithrombotic withdrawal, the safety and feasibility of continuing the antithrombotic medication perioperatively remain to be determined. The paucity of evidence-based data prompted us to conduct the current study.
| ¤ Materials and Methods|| |
The prospective cohort study included 115 patients who underwent TEP inguinal hernia repair between January 2015 and September 2016. Preoperatively, a total of 17 patients (the antithrombotic group) had been treated with antiplatelets or anticoagulants, including aspirin in nine patients, clopidogrel in three, warfarin in two, and ticlopidine, dabigatran and dipyridamole in one, respectively. The other 98 patients were not taking any antithrombotic medications and were considered as the control group. In all patients, a conventional TEP hernia repair was performed as it has been described. All procedures were performed by a single surgeon. The study protocol was approved by a Local Institutional Review Board (01-X18-063).
Demographic data including age, gender, Body Mass Index, comorbidities, medications, pre-operative symptoms, the American Society of Anesthesiologists (ASA) score and hernia characteristics were prospectively collected. The intraoperative findings (the type and size of the inguinal hernia), operative time, conversion to open surgery and the intraoperative complications (peritoneal tear, inferior epigastric vessel injury and other visceral injury) were recorded. Post-operatively, we assessed and recorded the modified medical outcome score, analgesic requirements, post-operative complications, sero-haematoma formation, hospital stay, days of return to normal activity, hernia recurrence, major cardiovascular events within 30 days and follow-up period.
Continuous data were summarised as a mean ± standard deviation and categorical data were summarised as n (%). Data are compared using two-sample t-test for continuous data with normal distribution, Mann–Whitney U-test for continuous data without normal distribution, Pearson Chi-square or Fisher's exact test for categorical data. All statistical assessments are two-tailed and considered significant as P < 0.05. Statistical analyses were performed with IBM SPSS statistical software version 22 for Windows (IBM Corp., New York, USA).
| ¤ Results|| |
The demographic data of the 17 patients (the antithrombotic group) and 98 (the control group) are shown in [Table 1]. Both groups had a similar gender distribution, body habitus, whereas the antithrombotic group had a greater mean age (65.9 ± 8.0 vs. 57.7 ± 13.6, P= 0.002) and higher prevalence of hypertension (64.7% vs. 33.7%, P= 0.015), cardiovascular diseases (64.7% vs. 7.1%, P < 0.001), atrial fibrillation (23.5% vs. 0, P < 0.001), ischaemic heart disease (35.3% vs. 0, P < 0.001) and ASA ≥2 (94.1% vs. 81.6%, P= 0.005).
|Table 1: Demographics of the 115 patients who underwent total extraperitoneal inguinal hernia repair|
Click here to view
The operation time for the antithrombotic group was longer than that of the control group (92.06 ± 32.81 min vs. 72.33 ± 20.99 min, P= 0.015). None experienced conversion to open surgery in either group. The amount of blood loss was similar between the two groups, and none experienced blood transfusion. There was no significant difference regarding laterality, type and size of a hernia. The incidence of the peritoneal tear, inferior epigastric vessel injury and other visceral injury was not different between the two groups [Table 2].
[Table 3] shows the post-operative outcomes. The medical outcome scores on post-operative day 1 and day 7 and the analgesic requirement were not statistically different between the two groups. There was no difference in the post-operative complications (29.4% vs. 28.6%) and sero-haematoma formation (23.5% vs. 11.1%). There was no significant difference in hospital stays after the operations (23.72 ± 7.74 vs. 22.35 ± 10.33 h) and the time for return to normal daily activity (3.56 ± 1.74 vs. 3.63 ± 1.90). None experienced major cardiovascular events within 30 days.
| ¤ Discussion|| |
In the present study, TEP inguinal hernia repair was successfully completed in all patients with the continuation of their antithrombotics without any conversion, and there was no major bleeding or other severe complications during the intra-operative and post-operative period. The incidences of post-operative complications and sero-haematoma formation in the patients on antithrombotics were similar to the controls. These findings suggest that TEP hernia repair is a safe and feasible procedure in patients whose antithrombotics should not be withdraw before the procedure.
The perioperative management of antithrombotic therapy in TEP inguinal hernia repair has been rarely addressed in the literature. Wakasugi et al. in their study reported a series of TEP inguinal hernia repair in 22 patients on antithrombotic agents and 55 controls. The antithrombotic agents were discontinued in all the 22 patients; nine of them did not receive any adjunctive therapy and the other 13 received heparin bridging therapy. The clinical outcomes were similar between the antithrombotic and the control groups regarding the operative time, bleeding volume, hospital stay and the occurrence of sero-haematoma, haematoma and thrombotic events. More recently, the same investigating group further reported a series of single-port TEP hernia repairs, which comprised 92 patients on antithrombotic agents and 273 controls. The perioperative manipulation of the antithrombotic medications included discontinuation without heparin bridging in 53, discontinuation with heparin bridging in 36 and continuation in only three. The clinical outcomes among the three manipulations were similar about the operative time, bleeding volume, as well as the rate of sero-haematoma formation or wound infection. The post-operative hospital stay in patients with continued antithrombotics was significantly shorter than those with discontinuation. These findings generally suggest that TEP an inguinal hernia is safe when discontinuing the antithrombotic agents, with or without heparin bridging therapy.
However, to withdraw the antithrombotic therapy significantly increases the risk of thromboembolic events, especially in those with high cardiovascular risk., The current guidelines also recommend the perioperative management of the antithrombotic therapy should be determined by balancing the bleeding risk of the procedure and the thromboembolic risk of the patient., The continuation of antithrombotic therapy in TEP inguinal hernia repair has been rarely addressed in the literature. Moreover, to the best of our knowledge, the current study is by far the largest series. To achieve a successful procedure in patients on antithrombotics, several points in our technique should be recognised. First, the use of balloon dilators in creating the pre-peritoneal space at the beginning of this procedure should be done extremely carefully. We suggest that the blind balloon dilatation should be limited in the middle part, simply enough for the other two trocars to be inserted. Then, the pre-peritoneal dissection is continued laterally under vision to avoid significant bleeding. Second, all the surgical steps should be taken subtly. A perfect haemostasis should be achieved by cauterisation of all the bleeding areas. The more delicate dissection and haemostasis explain the longer operation time in the antithrombotic group. Third, at the end of the procedure, we suggest that one should turn down the abdominal pressure to 5 mmHg, to make sure there is no venous bleeding masked by a high abdominal pressure.
Without high-level evidence, the optimal approach to inguinal hernia repair remains to be determined. Previous studies have revealed that anticoagulants increase the risk of post-operative bleeding in open hernioplasty.,, On the other hand, Sanders et al. revealed that open inguinal hernia mesh repair can be safely performed in patients on warfarin with an INR of 3 or less. A recent study based on data from the Herniamed Hernia Registry revealed that coexisting coagulopathy and antithrombotic therapy are associated with a four-fold risk of post-operative bleeding after open or laparoscopic inguinal hernia repair. However, despite endoscopic inguinal hernia repair requiring an extensive dissection, the risk of bleeding complications and complication related reoperation appears to be lower. The study generally confirmed the view that the subtle dissection technique applied in the endoscopic repair procedure appears to present a low risk of bleeding, which makes it a safe and feasible procedure.
There are several limitations to the current study. First, the number of patients continuing antithrombotic agents was small, although this is by far the largest series we have seen in the literature. Further investigation with more patients enrolled is still required. Second, all the procedures in the series were performed by an experienced laparoscopic surgeon. Whether the results apply to a surgeon with less experience requires further investigation. Third, our results do not necessarily mean that all procedures should be performed with the continuation of antithrombotic agents. The decision should be still made by carefully balancing the benefit-risk ratio.
| ¤ Conclusions|| |
The present study revealed that in experienced hands laparoscopic TEP hernia repair is a feasible and safe procedure in patients with the continuation of their antithrombotic medications.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
| ¤ References|| |
Armstrong MJ, Schneck MJ, Biller J. Discontinuation of perioperative antiplatelet and anticoagulant therapy in stroke patients. Neurol Clin 2006;24:607-30.
Dunn AS, Turpie AG. Perioperative management of patients receiving oral anticoagulants: A systematic review. Arch Intern Med 2003;163:901-8.
García Rodríguez LA, Cea Soriano L, Hill C, Johansson S. Increased risk of stroke after discontinuation of acetylsalicylic acid: A UK primary care study. Neurology 2011;76:740-6.
Broderick JP, Bonomo JB, Kissela BM, Khoury JC, Moomaw CJ, Alwell K, et al.
Withdrawal of antithrombotic agents and its impact on ischemic stroke occurrence. Stroke 2011;42:2509-14.
Kim YD, Lee JH, Jung YH, Cha MJ, Choi HY, Nam CM, et al.
Effect of warfarin withdrawal on thrombolytic treatment in patients with ischaemic stroke. Eur J Neurol 2011;18:1165-70.
Burger W, Chemnitius JM, Kneissl GD, Rücker G. Low-dose aspirin for secondary cardiovascular prevention – Cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation – Review and meta-analysis. J Intern Med 2005;257:399-414.
McCormack K, Wake B, Perez J, Fraser C, Cook J, McIntosh E, et al.
Laparoscopic surgery for inguinal hernia repair: Systematic review of effectiveness and economic evaluation. Health Technol Assess 2005;9:1-203, iii-iv.
Köckerling F, Roessing C, Adolf D, Schug-Pass C, Jacob D. Has endoscopic (TEP, TAPP) or open inguinal hernia repair a higher risk of bleeding in patients with coagulopathy or antithrombotic therapy? Data from the herniamed registry. Surg Endosc 2016;30:2073-81.
Wakasugi M, Akamatsu H, Yoshidome K, Tori M, Ueshima S, Omori T, et al.
Totally extraperitoneal inguinal hernia repair in patients on antithrombotic therapy: A retrospective analysis. Surg Today 2013;43:942-5.
Wakasugi M, Tei M, Suzuki Y, Furukawa K, Masuzawa T, Kishi K, et al.
Single-incision totally extraperitoneal inguinal hernia repair is feasible and safe in patients on antithrombotic therapy: A single-center experience of 92 procedures. Asian J Endosc Surg 2017;10:301-7.
Ho CH, Liao PW, Yang SS, Jaw FS, Tsai YC. The use of porcine small intestine submucosa implants might be associated with a high recurrence rate following laparoscopic herniorrhaphy. J Formos Med Assoc 2015;114:216-20.
Baron TH, Kamath PS, McBane RD. Management of antithrombotic therapy in patients undergoing invasive procedures. N Engl J Med 2013;368:2113-24.
Fleisher LA, Fleischmann KE, Auerbach AD, Barnason SA, Beckman JA, Bozkurt B, et al.
2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: Executive summary: A report of the American College of Cardiology/American Heart Association task force on practice guidelines. Circulation 2014;130:2215-45.
Bombuy E, Mans E, Hugué A, Plensa E, Rodriguez L, Prats M, et al.
Elective inguinal hernioplasty in patients on chronic anticoagulation therapy. Management and outcome. Cir Esp 2009;86:38-42.
Sanders DL, Shahid MK, Ahlijah B, Raitt JE, Kingsnorth AN. Inguinal hernia repair in the anticoagulated patient: A retrospective analysis. Hernia 2008;12:589-92.
McLemore EC, Harold KL, Cha SS, Johnson DJ, Fowl RJ. The safety of open inguinal herniorraphy in patients on chronic warfarin therapy. Am J Surg 2006;192:860-4.
[Table 1], [Table 2], [Table 3]