| ORIGINAL ARTICLE
|Year : 2019 | Volume
| Issue : 2 | Page : 115-118
Changes of serum and peritoneal inflammatory mediators in laparoscopic radical resection for right colon carcinoma
Pengcheng Zhu1, Wenzhong Miao1, Feng Gu1, Chungen Xing2
1 Department of General Surgery, First People's Hospital of Changshu City, Changshu Hospital Affiliated to Soochow University, Changshu, China
2 Department of Colorectal Surgery, Second Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, China
Objective: The objective of this study is to investigate the effects of laparoscopic and open operation on serum and peritoneal inflammatory mediators in patients with right colon carcinoma.
Patients and Methods: A total of 100 patients were randomly divided into laparoscopic group (n = 50) and open group (n = 50). The age, sex, operation time, operation blood loss, post-operative Dukes stage, time to first passage of flatus and post-operative hospital stay were recorded. The levels of hypersensitive C reactive protein (hsCRP) and tumour necrosis factor-α (TNF-α) in serum and abdominal exudate were measured by ELISA at the time of pre-operative 2 h and post-operative 6 h and 24 h.
Results: There was no significant difference in age, sex, Dukes stage and pre-operative inflammatory mediators between the two groups (P > 0.05). The operation time, intraoperative blood loss, time to first passage of flatus and post-operative hospital stay were significantly better in laparoscopic group than those in open operation group. At 6 h and 24 h after operation, the levels of hsCRP and TNF-α in serum and abdominal exudate in laparoscopic group were significantly lower than those in open operation group.
Conclusions: Laparoscopic surgery for the treatment of right colon carcinoma has the advantages of fewer traumas, less systemic and local inflammatory response, rapider post-operative recovery and shorter hospital stay. It is worthy of clinical application.
Prof. Chungen Xing
Department of Colorectal Surgery, Second Hospital Affiliated to Soochow University, 1055 Sanxiang Road, Suzhou 215004, Jiangsu Province
Source of Support: None, Conflict of Interest: None
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