|Year : 2015 | Volume
| Issue : 1 | Page : 83-86
Robotic assisted laparoscopic adrenalectomy: Initial experience from a tertiary care centre in India
Mrinal Pahwa1, Archna Rautela Pahwa2, Radhika Batra3, Rtika Ryfka Abraham4, Arun Chawla5, Sachin Kathuria1, Ajay Sharma1
1 Department of Urology, Sir Ganga Ram Hospital, New Delhi, India
2 Department of Pathology, Lady Hardinge Medical College, New Delhi, India
3 Department of Radiology, Maulana Azad Medical College, New Delhi, India
4 Department of Endocrinology, University of Arkansas Medical Sciences, Hofstra, USA
5 Department of Nephrology, South Kidney Specialist, Hofstra, USA
|Date of Submission||14-Apr-2014|
|Date of Acceptance||14-Jun-2014|
|Date of Web Publication||24-Dec-2014|
78-C, Mianwali Colony, Gurgaon - 122 001, Haryana
Source of Support: None, Conflict of Interest: None
Introduction: Laparoscopic adrenalectomy (LA) is now considered the standard for treatment of surgically correctable adrenal disorders. Robotic adrenalectomy has been performed worldwide and has established itself as safe, feasible and effective approach. We hereby present the first study in robotic transperitoneal LA from Indian subcontinent. Materials and Methods: We conducted a retrospective evaluation of 25 patients who had undergone robotic assisted LA at a tertiary health centre by a single surgeon. Demographic, clinical, histopathological and perioperative outcome data were collected and analysed. Results: Mean age of the patients was 45 years (range: 27-65 years). Eleven male and 14 female patients were operated. Mean operative time was 139 min ± 30 min (range: 110-232 min) and mean blood loss was 85 ml ± 12 ml (range: 34-313 ml). Mean hospital stay was 2.5 ± 1.05 days (range: 2-6 days). Mean visual analogue scale score was 3.2 (range: 1-6) mean analgesic requirement was 50 mg diclofenac daily (range: 0-150 mg). Histopathological evaluation revealed 11 adenomas, eight phaeochromocytomas, two adrenocortical carcinomas, and four myelolipomas. According to Clavien-Dindo classification, three patients developed Grade I post-operative complications namely hypotension and pleural effusion. Conclusion: Robotic adrenalectomy is safe, technically feasible and comfortable to the surgeon. It is easier to perform with a short learning curve.
Keywords: Laparoscopic adrenalectomy, laparoscopy, myelolipoma, phaeochromocytoma, robotic adrenalectomy
|How to cite this article:|
Pahwa M, Pahwa AR, Batra R, Abraham RR, Chawla A, Kathuria S, Sharma A. Robotic assisted laparoscopic adrenalectomy: Initial experience from a tertiary care centre in India. J Min Access Surg 2015;11:83-6
|How to cite this URL:|
Pahwa M, Pahwa AR, Batra R, Abraham RR, Chawla A, Kathuria S, Sharma A. Robotic assisted laparoscopic adrenalectomy: Initial experience from a tertiary care centre in India. J Min Access Surg [serial online] 2015 [cited 2019 Jun 25];11:83-6. Available from: http://www.journalofmas.com/text.asp?2015/11/1/83/147704
| ¤ Introduction|| |
In recent times, laparoscopic adrenalectomy (LA) has been regarded as the preferred surgical approach for the treatment of most surgically correctable benign adrenal disorders and certain malignant tumours. LA has replaced the conventional open procedure and is accepted as the treatment of choice for patients with benign adrenal lesions.  Recently, robotic technology has been introduced into laparoscopic clinical practice. In 2001, Horgan and Vanuno reported on the first robotic adrenalectomy.  The robotic system offers certain advantages over traditional laparoscopic surgery such as three-dimensional optics, magnified view with excellent resolution and depth perception, 7° of freedom at wrists for operating instruments, filtering out tremors, and allowing precise movements. In addition, the surgeon has control of a steady camera, two operating robotic arms, and an optional fourth arm, which can be used as a retractor. Last but not the least; it enables the surgeon to operate in a comfortably seated position. These advantages could theoretically improve LA procedure and then lead to improved peri- and post-operative outcomes.
We hereby describe our initial experience of robot assisted LA at our institute including functional and oncological outcomes.
| ¤ Materials and methods|| |
We conducted a retrospective evaluation of patients who underwent adrenalectomy at our institute. In total, 25 robot assisted laparoscopic adrenalectomies were carried out in our department from February 2012 to April 2013 by a single surgeon. The operating surgeon had an adequate experience of open and laparoscopic adrenalectomies. Demographic, perioperative, pathologic, and oncological outcome data were collected and analysed. Visual analogue scale (VAS) was used to assess the pain in the postoperative period. Pain score was obtained once daily until the patients got discharged from the hospital before the administration of analgesics. 50 mg diclofenac was given to the patient if the VAS score was above 2. A surgeon fatigue index (SFI) was calculated according to the numerological rating scale. It is not a validated tool, but just a rough estimate of surgeon's fatigue. The operating surgeon was asked to rate the discomfort after completion of the surgery on a scale of 1-10. Five patients had undergone open adrenalectomy during this period. The reasons for performing open adrenalectomy were increased size (>10 cm), infiltrative tumours and financial issues. Patients with suspicion of phaeochromocytoma underwent the same pre-operative pharmacological management with alpha-blocker as in open surgery.
The surgical technique is essentially similar to laparoscopic surgery. The patient is placed in modified flank position with table break at the level of the 12 th rib. The Da Vinci (DV) robot surgery system is docked over the ipsilateral shoulder. Initially, the table's position was changed according to the robot, but now we prefer to move around the robot according to the position of the patient as we observed faster docking with this technique. Pneumoperitoneum is made by veress needle at the lateral margin of rectus muscle two-finger breadth above umbilicus. We normally use only 30° down scope for dissection and two robotic arms for two instruments namely fenestrated bipolar forceps and the cautery hook. Four ports are used on either side with an additional fifth port used occasionally on the right side for retracting liver. The port position is as shown in [Figure 1] and [Figure 2]. The key steps involved in right adrenalectomy include division of the triangular ligament, division of gerotas fascia, early identification and division of adrenal vein at its junction with inferior vena cava, mobilisation of the adrenal gland posteriorly, laterally and from kidney inferiorly. The same techniques apply on left side also except for mobilisation of spleen and division of splenocolic ligament and identification of adrenal vein at its junction with renal vein. Meticulous care is taken to avoid manipulation of tumour, and periadrenal tissues are used for grasping the adrenal gland. According to the operating surgeon, use of robot is especially advantageous in dissecting and clipping adrenal vein with minimal manipulation of the adrenal gland.
| ¤ Results|| |
The various demographic data and patient profile is shown in [Table 1]. Mean age of the patients was 45 years. Eleven patients were male, and 14 were female. Fifteen patients were operated for left side tumours, and ten had right side tumours. Two patients developed intra-operative hypertension that was controlled easily with intravenous nitoglycerine drip. There was no incidence of any arrhythmias intra-operatively or post-operatively. The mean console time was 139 min ± 30 min which was considerably lesser than reported for laparoscopic cases in the literature. Initially, the mean docking time for first 15 cases was roughly 35 min that got reduced to 22 min for next 10 cases. The mean intraoperative blood loss was 85 ml ± 12 ml. Only one adrenocortical cancer patient had significant bleeding that needed blood transfusion. The mean hospital stay was 2.5 ± 1.05 days. Patients were mostly pain-free during the hospital stay. Pain score was calculated daily until the patient was discharged from the hospital using numerical rating scale. Mean VAS score was 3.2 (range: 1-6). The daily analgesic requirement was approximately 50 mg of diclofenac. According to Clavien-Dindo classification, three patients developed Grade I post-operative complications namely hypotension and pleural effusion. No Grade 2 or higher complications were present. Hypotension occurred in the immediate post-operative period in patients harbouring phaeochromocytoma and was managed with intravenous fluids. Pleural effusion was mild and mostly reactive. It was observed in patients with upper polar tumours. There was no respiratory distress and effusion resolved on its own. There was no mortality. The mean SFI based on a numerological rating scale was found to be a low 2.4 (range: 1.5-6).
We compared these patients with another cohort of patients who underwent LA over the last 5 years. [Table 2] depicts a comparison between laparoscopic and robotic group in terms of demographic and operative parameters.
|Table 2: Comparison of the patients undergoing laparoscopic and robotic adrenalectomy|
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| ¤ Discussion|| |
In the last decade, LA has been established as standard of care for benign adrenal disease ,,,, and increasingly considered for selected malignant lesions. ,,, First described in 1992,  LA has been shown to be well-tolerated, reduce patient morbidity, decrease costs, and shorten convalescence compared with open surgery. ,,,, However, surgeons need to confront some disadvantages during traditional laparoscopy, including an unstable operating field, orientation error due to camera holding and manipulation by the assistant, limitation of range and freedom of movement, inferior ergonomic design of the instruments, natural hand fatigue, tremors, and a two-dimensional operative field. Gill et al. first demonstrated the feasibility and effectiveness of adrenal surgery in a porcine model.  Subsequently Horgan and Vanuno  reported the first robotic adrenalectomy in humans. Since then more than 50 studies have been published on robotic adrenalectomy, ,,,,,,,,, but only few studies had more than 20 patients. ,,,,, All in all, robotic surgery has proved to be a useful and significant advancement in performing adrenalectomies. It has proved to be equally efficacious if not superior to the LA. Newer modifications and advances have been made in robotic adrenalectomy such as retroperitoneal adrenalectomy and partial adrenalectomy. The disadvantages are lack of tactile feedback with robotic instruments, inability to reposition the patient once the robot is docked, and limited options for tissue coagulation devices such as the harmonic scalpel (non-wristed instrument). The lack of tactile feedback requires surgeons to rely on visual cues and experience to avoid tissue injury, which is not a trivial issue.
The conversion rate from robotic to open is reasonably low and comparable to LA. In one of the initial large series, Brunaud et al. reported a conversion rate of 7%.  Subsequent series also reported a low conversion rate in the range of 5-8%. ,, The main reasons for conversion are difficult or aberrant anatomy, uncontrolled bleeding and large size of the tumour. We didn't have any conversion perhaps because of stringent preoperative selection criteria. Brunaud et al.  have reported that patients who were converted to open adrenalectomy had a body mass index (BMI) Z29 kg/m 2 (three out of four), tumour size >6 cm (two out of four), or pheochromocytoma (two out of four).
Studies on robotic adrenalectomy have all demonstrated reasonably low complication rates and morbidity. Morino et al. described two cases of severe intra-operative hypertension in their series of 10 patients.  The basic principles of surgery for phaeochromocytoma remain the same and apply as well in robotic surgery. The tumour should be minimally manipulated, and adrenal should be grasped by periadrenal tissues. Proper identification of planes and upward traction by bipolar forceps is equally important to avoid inadvertent manipulation. We also experienced two cases of intra-operative rise in blood pressure that were adequately controlled by intravenous nitroglycerine drip and fluid management. The pharmacological pre-operative preparation of phaeochromocytoma remains the same irrespective of the approach used.
Length of hospital stay has been shown to be equivalent between robotic and LA. , It has mainly ranged from 2 to 6 days. The mean hospital stay in our series was also similar to that reported in the literature. Besides hospital stay, we observed that the patient had considerably lesser post-operative analgesic requirement as compared with open surgery.
In comparison to pure laparoscopic approach, robotic adrenalectomy has longer operative time. In 2006, the median operative time was reported to be 185 min by Winter et al. on a series of 30 RAs performed by 3 surgeons at a single institution.  In another study by Brunaud,  mean operative time decreased significantly (P = 0.03) from 101 min in the first 50 cases to 88 min for the last 45 cases (five conversions were excluded). Nordenstrom et al.  showed that the median skin-to-skin time for all 100 patients was 113 min (25 and 75 percentiles, 92-159 min), and 106 (range: 58-343) for the last 50 patients. The skin-to-skin time decreased significantly with the number of patients (P = 0.0001). The median console operation time for the whole series was 88 min (range: 39-397 min). In a recent study, Giulianotti et al.  showed that mean operative time was 118 min. Interestingly, the difference in operative times between the latest robot version (DVs system with four arms) and the previous one (DV system) was not significant (115 vs. 122 min; P = 0.65). Robotic adrenalectomy may though confer a time advantage for obese patients; Brunaud et al. in two papers , noted positive correlation between patient's BMI (>30 kg/m 2 ) and duration of LA, but no correlation in patients having the robotic procedure. In one study, larger tumour size (>55 mm) increased operative time for LA compared with robotic adrenalectomy, but this difference did not exist with smaller tumours. Other factors that might improve operative times for robotic adrenalectomy are side (right > left), experience of the side surgeon, and laparoscopic experience of the primary surgeon.  We observed that docking time and the overall time decreased with increasing experience of the operation theatre personnel and operating surgeon.
| ¤ Conclusion|| |
Robotic adrenalectomy is feasible, well-tolerated and produces the desirous result along with ease to the surgeon based on shorter operative time, lesser blood loss, and lesser pain score, lesser SFI and shorter hospital stay. This is the first series of robotic adrenalectomy from Indian subcontinent. Limitations of our study include a small number of patients, short follow-up and lack of cost analysis. The start-up costs, cost of maintenance of the robot, and cost of disposables that are used in each robotic case compared to similar laparoscopic procedures in addition to the marketing value of the robot are not evaluated in this study.
| ¤ References|| |
Schell SR, Talamini MA, Udelsman R. Laparoscopic adrenalectomy for nonmalignant disease: Improved safety, morbidity, and cost-effectiveness. Surg Endosc 1999;13:30-4.
Horgan S, Vanuno D. Robots in laparoscopic surgery. J Laparoendosc Adv Surg Tech A 2001;11:415-9.
Gagner M, Pomp A, Heniford BT, Pharand D, Lacroix A. Laparoscopic adrenalectomy: Lessons learned from 100 consecutive procedures. Ann Surg 1997;226:238-46.
Zeh HJ 3 rd
, Udelsman R. One hundred laparoscopic adrenalectomies: A single surgeon's experience. Ann Surg Oncol 2003;10:1012-7.
Hazzan D, Shiloni E, Golijanin D, Jurim O, Gross D, Reissman P. Laparoscopic vs open adrenalectomy for benign adrenal neoplasm. Surg Endosc 2001;15:1356-8.
Guazzoni G, Montorsi F, Bocciardi A, Da Pozzo L, Rigatti P, Lanzi R, et al.
Transperitoneal laparoscopic versus open adrenalectomy for benign hyperfunctioning adrenal tumors: A comparative study. J Urol 1995;153:1597-600.
Tsuru N, Ushiyama T, Suzuki K. Laparoscopic adrenalectomy for primary and secondary malignant adrenal tumors. J Endourol 2005;19:702-8.
Moinzadeh A, Gill IS. Laparoscopic radical adrenalectomy for malignancy in 31 patients. J Urol 2005;173:519-25.
Corcione F, Miranda L, Marzano E, Capasso P, Cuccurullo D, Settembre A, et al.
Laparoscopic adrenalectomy for malignant neoplasm: Our experience in 15 cases. Surg Endosc 2005;19:841-4.
Henry JF, Defechereux T, Raffaelli M, Lubrano D, Gramatica L. Complications of laparoscopic adrenalectomy: Results of 169 consecutive procedures. World J Surg 2000;24:1342-6.
Gagner M, Lacroix A, Bolté E. Laparoscopic adrenalectomy in Cushing's syndrome and pheochromocytoma. N Engl J Med 1992;327:1033.
Prinz RA. A comparison of laparoscopic and open adrenalectomies. Arch Surg 1995;130:489-92.
Smith CD, Weber CJ, Amerson JR. Laparoscopic adrenalectomy: New gold standard. World J Surg 1999;23:389-96.
Ishikawa T, Sowa M, Nagayama M, Nishiguchi Y, Yoshikawa K. Laparoscopic adrenalectomy: Comparison with the conventional approach. Surg Laparosc Endosc 1997;7:275-80.
Gill IS, Sung GT, Hsu TH, Meraney AM. Robotic remote laparoscopic nephrectomy and adrenalectomy: The initial experience. J Urol 2000;164:2082-5.
Brunaud L, Bresler L, Ayav A, Zarnegar R, Raphoz AL, Levan T, et al.
Robotic-assisted adrenalectomy: What advantages compared to lateral transperitoneal laparoscopic adrenalectomy? Am J Surg 2008;195:433-8.
Winter JM, Talamini MA, Stanfield CL, Chang DC, Hundt JD, Dackiw AP, et al.
Thirty robotic adrenalectomies: A single institution's experience. Surg Endosc 2006;20:119-24.
Brunaud L, Bresler L, Zarnegar R, Ayav A, Cormier L, Tretou S, et al.
Does robotic adrenalectomy improve patient quality of life when compared to laparoscopic adrenalectomy? World J Surg 2004;28:1180-5.
Brunaud L, Bresler L, Ayav A, Tretou S, Cormier L, Klein M, et al.
Advantages of using robotic Da Vinci system for unilateral adrenalectomy: Early results. Ann Chir 2003;128:530-5.
Giulianotti PC, Buchs NC, Addeo P, Bianco FM, Ayloo SM, Caravaglios G, et al.
Robot-assisted adrenalectomy: A technical option for the surgeon? Int J Med Robot 2011;7:27-32.
Nordenstrom E, Westerdahl J, Hallgrimsson P, Bergenfelz A. A prospective study of 100 robotically-assisted laparoscopic adrenalectomies. J Robot Surg 2011;5:127-31.
Morino M, Benincà G, Giraudo G, Del Genio GM, Rebecchi F, Garrone C. Robot-assisted vs laparoscopic adrenalectomy: A prospective randomized controlled trial. Surg Endosc 2004;18:1742-6.
Wu JC, Wu HS, Lin MS, Chou DA, Huang MH. Comparison of robot-assisted laparoscopic adrenalectomy with traditional laparoscopic adrenalectomy-1 year follow-up. Surg Endosc 2008;22:463-6.
Desai MM, Gill IS, Kaouk JH, Matin SF, Sung GT, Bravo EL. Robotic-assisted laparoscopic adrenalectomy. Urology 2002;60:1104-7.
Krane LS, Shrivastava A, Eun D, Narra V, Bhandari M, Menon M. A four-step technique of robotic right adrenalectomy: Initial experience. BJU Int 2008;101:1289-92.
[Figure 1], [Figure 2]
[Table 1], [Table 2]